The parent fatty acid for omega-3s is α-linolenic (ALA) acid and for omega-6s the parent fatty acid is linoleic acid (LA). LA is converted to the biologically active omega-6 fatty acid, arachidonic acid (AA), which is involved in cell-signaling pathways and functions as a precursor for proinflammatory eicosanoids. ALA is converted to the biologically active omega-3 fatty acid, EPA, which, in turn, is converted to the omega-3 fatty acid, DHA. DHA is the critical component of cell membranes in the brain and retina, where it is involved in visual and neural function as well as neurotransmitter metabolism.8 The accumulation of DHA begins in utero and is derived predominantly through placental transfer. Ultimately, fetal DHA concentrations are determined by maternal diet as the human body is not efficient at converting ALA to DHA.
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